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The Only Drugs Ive Ever Taken Are:

Coffee,
Alcohol,
Chocolate.

The rest, will never and have never touched. Even though some of my friends are druggys

The Only Drugs Ive Ever Taken Are:

Coffee,
Alcohol,
Chocolate.

The rest, will never and have never touched. Even though some of my friends are druggys

since when was chocolate a drug?
or coffee...i know it has caffiene in it but you know caffiene doesn't really count as a drug imo...its basically harless when used in moderation just like anything else....its like calling sugar adrug cause you can get hyper from it

Natuaral means nothing.
Many drugs are natural.
Nature can produce deadly toxics who can kill you with ease, don't think natural is safe.



QFT

since when was chocolate a drug?
or coffee...i know it has caffiene in it but you know caffiene doesn't really count as a drug imo...its basically harless when used in moderation just like anything else....its like calling sugar adrug cause you can get hyper from it

since when was chocolate a drug?
or coffee...i know it has caffiene in it but you know caffiene doesn't really count as a drug imo...its basically harless when used in moderation just like anything else....its like calling sugar adrug cause you can get hyper from it

yes nature can make extremely deadly toxins.
But are those toxins are in peyote, mushrooms, marijuana, salvia, I dont really feel like looking up every natural drug, ?

Coffee is not a drug. Stop calling Coffee a drug its stupid, its the equivilant of FOX News makeing a story about e-mail addiction. Just because Someone decides to label something as whatever they wann't doesn't it so. When i drink soda i am not taking drugs, when i drink tea im nto taking drugs, when i drink coffee im not friggin takin any drugs.

dude get this right coffee is not a drug but caffeine is

If you ingest alot off sugar you get the same results as ingesting caffeine. So why isn't sugar labled as a drug? Drugs are defined as anythign that alters the function of the body so if ingesting sugar can give you the same effects as ingesting coffeee why doesn't the FDA monitor sugar consumption and label it as a drug? Coffee is only labled as adrug because the FDA says so (and yes they do have the power to say what is and what is not a drug in the US). Basically im trying to say there are drugs and there are "drugs" and just because someone tells me a "drug" is a drug isn't a good reason for me to consider it in the same catagory as real drugs.

no you dont trust me taking alot of sugar is not the same as taking alot of caffeine
but w/e believe what you want

that caffeine is not harmful in moderation and in moderation its effects are no more dangerous than consuming slightly excessive amounts of sugar and because of that people should not loop it in the same catagory as other real drugs like crack, weed, and heroine

you make absolutly no sense. I say I like drugs that are natural.. and you say nature can also make deadly toxins. These deadly toxins don't even exist in the drugs that im talking about .... and now you are saying you're studying toxins?

1) Caffeine is a part of the Xanthines.

With Caffeine, Theobromine and Theophyline as 3 resembling molecules.
The only difference is the amount and relative place of the Methylgroups on the molecule.


Caffeinelkjgdlkgzae'tzaefmhmljdhftheobromine jgsqdlifmhezatzzer Theophylline.

They have diuretic effects (Theophylline > theobromine > caffeine)
They also have a positive inotrope effect, meaning they'll increase the force of a heartbeat. They also increase heartbeat and dilates the coronaric arteries. They also have central effects, and trigger brochodilatation.

Increase of physic activity: (caffeine > theophylline >>> theobromine)

Main uses.
Caffeine: psychotonic (sp?)
Theophylline: coronaric dilator, diuretic
Theobromine:


I got that from my course called pharmaceutical chem.
It might not be really clear, because translation wasn't that easy, but I can assure caffeine is a drug.

Sugar isn't one. Increased sugar levels could make one active, but that's because it's metabolized into ATP, the main energy source in your body. and off course it triggers the release of certain hormones, because your body wants the amount off sugar in ones blood at a certain level, but that doesn't make it a drug.

Caffeine acts through multiple mechanisms involving both action on receptors and channels on the cell membrane, as well as intracellular action on calcium and cAMP pathways. By virtue of its purine structure it can act on some of the same targets as adenosine related nucleosides and nucleotides, like the cell surface P1 GPCRs for adenosine, as well as the intracellular Ryanodine receptor which is the physiological target of cADPR (cyclic ADP ribose), and cAMP-phosphodiesterase (cAMP-PDE). Although the action is agonistic in some cases, it is antagonistic in others. Physiologically, however, caffeine action is unlikely due to increased RyR opening, as it requires plasma concentration above lethal dosage. The action is most likely through adenosine receptors.

Like alcohol, nicotine, and antidepressants, caffeine readily crosses the blood brain barrier. Once in the brain, the principal mode of action of caffeine is as an antagonist of adenosine receptors found in the brain.[31] The caffeine molecule is structurally similar to adenosine, and binds to adenosine receptors on the surface of cells without activating them (an "antagonist" mechanism of action). Therefore, caffeine acts as a competitive inhibitor. The reduction in adenosine activity results in increased activity of the neurotransmitter dopamine, largely accounting for the stimulatory effects of caffeine. Caffeine can also increase levels of epinephrine/adrenaline,[32] possibly via a different mechanism. Acute usage of caffeine also increases levels of serotonin, causing positive changes in mood.

The inhibition of adenosine may be relevant in its diuretic properties. Because adenosine is known to constrict preferentially the afferent arterioles of the glomerulus, its inhibition may cause vasodilation, with an increase in renal blood flow (RBF) and glomerular filtration rate (GFR). This effect, called competitive inhibition, interrupts a pathway that normally serves to regulate nerve conduction by suppressing post-synaptic potentials. The result is an increase in the levels of epinephrine and norepinephrine/noradrenaline released via the hypothalamic-pituitary-adrenal axis.[33] Epinephrine, the natural endocrine response to a perceived threat, stimulates the sympathetic nervous system, leading to an increased heart rate, blood pressure and blood flow to muscles, a decreased blood flow to the skin and inner organs. Biochemically, it stimulates glycogenolysis, inhibits glycolysis, and stimulates gluconeogenesis to produce more glucose in the muscles and release of glucose into the blood stream from the liver.

Caffeine is also a known competitive inhibitor of the enzyme cAMP-phosphodiesterase (cAMP-PDE), which converts cyclic AMP (cAMP) in cells to its noncyclic form, allowing cAMP to build up in cells. Cyclic AMP participates in activation of Protein Kinase A (PKA) to begin the phosphorylation of specific enzymes used in glucose synthesis. By blocking its removal caffeine intensifies and prolongs the effects of epinephrine and epinephrine-like drugs such as amphetamine, methamphetamine, or methylphenidate. Increased concentrations of cAMP in parietal cells causes an increased activation of protein kinase A (PKA) which in turn increases activation of H+/K+ ATPase, resulting finally in increased gastric acid secretion by the cell.

Caffeine (and theophylline) can freely diffuse into cells and causes intracellular calcium release (independent of extracellular calcium) from the calcium stores in the Endoplasmic Reticulum(ER). This release is only partially blocked by Ryanodine receptor blockade with ryanodine, dantrolene, ruthenium red, and procaine (thus may involve ryanodine receptor and probably some additional calcium channels), but completely abolished after calcium depletion of ER by SERCA inhibitors like Thapsigargin (TG) or cyclopiazonic acid (CPA).[34] The action of caffeine on the ryanodine receptor may depend on both cytosolic and the luminal ER concentrations of Ca2+. At low millimolar concentration of caffeine, the RyR channel open probability (Po) is significantly increased mostly due to a shortening of the lifetime of the closed state. At concentrations >5 mM, caffeine opens RyRs even at picomolar cytosolic Ca2+ and dramatically increases the open time of the channel so that the calcium release is stronger than even an action potential can generate. This mode of action of caffeine is probably due to mimicking the action of the physiologic metabolite of NAD called cADPR (cyclic ADP ribose) which has a similar potentiating action on Ryanodine receptors.

Caffeine may also directly inhibit delayed rectifier and A-type K+ currents and activate plasmalemmal Ca2+ influx in certain vertebrate and invertebrate neurons.

The metabolites of caffeine contribute to caffeine's effects. Theobromine is a vasodilator that increases the amount of oxygen and nutrient flow to the brain and muscles. Theophylline, the second of the three primary metabolites, acts as a smooth muscle relaxant that chiefly affects bronchioles and acts as a chronotrope and inotrope that increases heart rate and efficiency. The third metabolic derivative, paraxanthine, is responsible for an increase in the lipolysis process, which releases glycerol and fatty acids into the blood to be used as a source of fuel by the muscles.[35]

omg, drop the caffeine thing lol.

maybe it's a drug but it's almost harmless.

Drop the maybe and I'll agree with you.

/drop maybe

I tried to get both of you satisfied. ^^

Oh shit. Now I'm in the caffeine-argue. ^^

Scrap the caffeine. It makes ur blood pressure high.-> really unhealthy.

My body hates me already.
Smoking is worse as 2 cups of coffee.

Oh shit. Now I'm in the caffeine-argue. ^^